Paraneoplastic sensory ganglionopathy is thought to be caused by cytotoxic T cells stimulated by antigens in the tumor that cross-react with epitopes on sensory ganglia neurons. Furthermore, ganglia may be susceptible to autoimmune attack because of the fenestrated endothelial cells that form a permeable blood–nerve barrier. The importance of sensory ganglia, in addition to the unique topography of sensory loss that occurs when they are diseased, lies in their close association with general medical disorders, and paraneoplastic disorders in particular. Their proximal projections are the sensory nerve roots that enter the spinal cord, and their peripheral projections are the sensory fibers of peripheral nerves. 1-5 The sensory ganglia contain the cell bodies of the sensory nerves and lie alongside both sides of the spinal cord, appended to the dorsal root of each spinal nerve.
These disorders are called sensory neuronopathies or sensory ganglionopathies. The most trusted, influential source of new medical knowledge and clinical best practices in the world.Īmong disorders that cause sensory loss, the most distinctive are those that affect the sensory ganglia.
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